Modeling of airborne embryotoxic volatile organic compounds (VOCs) in the IVF culture environment – their concomitant cytotoxic concentration within the growth media and embryo

Modeling of airborne embryotoxic volatile organic compounds (VOCs) in the IVF culture environment – their concomitant cytotoxic concentration within the growth media and embryo
VOCs are a common component of laboratory ambient air. VOCs are unique in their polarity, molecular weight and structure and play a critical role in preimplantation toxicology and epigenetic processes. This study sought to define the mechanisms of cytotoxicity associated with VOCs found in the IVF culture environment. The concomitant concentrations of VOCs common to IVF laboratories were modeled with Henry’s Law (HL) from the gaseous to aqueous phase, and the final resulting concentration within the embryo was modeled with octanol water partitioning coefficients (OWPC).
Source: fertstert.org