Embryos classified as low-grade mosaic (<50%) after preimplantation genetic screening (PGS) by means of high resolution next-generation screening (hr-NGS), can have the same competence of producing healthy newborns as euploid embryos
Mosaic preimplantation embryos contain two or more cell lines with different chromosome content, the consequence of errors in chromosome segregation occurring during mitotic divisions. Recently the NGS was validated and implemented for PGS. There are several different platforms, with different resolutions, that can detect mosaicism to a different extent. Veriseq NGS (Illumina) that was used in our study, can detect mosaicism when aneuploidy is present in 20%-80% of TE cells biopsied from a blastocyst.
Source: fertstert.org
Embryos classified as low-grade mosaic (<50%) after preimplantation genetic screening (PGS) by means of high resolution next-generation screening (hr-NGS), can have the same competence of producing healthy newborns as euploid embryos
Published in Embryology and Reproductive Medicine
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