Letrozole versus clomiphene in polycystic ovary syndrome—more than one way to crack an egg

Letrozole versus clomiphene in polycystic ovary syndrome—more than one way to crack an egg
Polycystic ovary syndrome (PCOS) is a common cause of anovulatory infertility. Optimal ovulation induction would achieve ovulation and live birth while minimizing the risk of multiple gestations, birth defects, side-effects, and cost. The optimal first-line agent has evolved based on several notable randomized controlled trials with surprising results. First, based on early data on the value of metformin for ovulation in PCOS, Legro et al. designed a randomized trial (RT) of extended-release metformin, clomiphene citrate (CC), or both to test the hypothesis that metformin would result in a higher live birth rate than CC and that the combination would result in a superior live birth rate (1).
Source: fertstert.org