Old is bad, young is good but what about very young? Oocytes obtained from pre-pubertal ovarian tissue of very young patients are incapable of in vitro maturation

Old is bad, young is good but what about very young? Oocytes obtained from pre-pubertal ovarian tissue of very young patients are incapable of in vitro maturation
Currently, the only fertility preservation option for prepubertal girls is storage of ovarian cortical tissue with the potential for reimplantation later in life. The excellent cancer survival rates of prepubertal children after chemo/radiotherapy are somehow diminished in value by the limited options available for preserving future fertility. The paper by Karavani and colleagues (1) in this issue expands much needed research in pre-menarche ovarian and follicle physiology by exploring the maturation competence of immature oocytes harvested from the ovarian cortex of prepubertal girls.
Source: fertstert.org